general tests fpgee practice test

Which of the following enzymes could metabolize ethanol?

• A. Cytochrome P450
• B. Alcohol Dehydrogenase
• C. Glucuronyl Transferase
• D. Sulfotransferase
• E. All of the above

Which of the following are similarities between Cytochrome P450 and MAO?

• A. Both add oxygen from O2 to substrates and also form water
• B. Both carry out direct heteroatom oxidations
• C. Both carry out oxidative deaminations
• D. Both carry out N-dealkylations
• E. All of the above

What would be the preferred route of metabolism of succinyl choline?

• A. Ester hydrolysis
• B. N-oxidation
• C. Glucuronide conjugation
• D. A & B
• E. All of the above

Which of the following causes the smallest change in solubility?

• A. Hydroxylation
• B. Glucuronidation
• C. Sulfation
• D. Glutathione conjugation

Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily
metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic
patient in hospital who could not smoke?

• A. No change
• B. Increase
• C. Decrease

Which of the following is the antidote for the toxin Benzodiazepines?

• A. Flumazenil
• B. Methylene blue
• C. Deferoxamine
• D. Alkalinize urine

Which of the following is the antidote for the toxin Lead?

• A. Naloxone
• B. Nitrite
• C. CaEDTA
• D. Dialysis

Which of the following is the primary site of activity for the drug Warfarin?

• A. Kidney
• B. Liver
• C. Blood
• D. Heart

Lansoprazole is not used in which of the following cases?

• A. Gastritis
• B. Peptic Ulcers
• C. Zollinger-Ellison syndrome
• D. Thalamus hypertrophy

Which of the following drugs is associated with the reaction of Cinchonism?

• A. Valproic acid
• B. Quinidine
• C. Isoniazid
• D. Ethosuximide